ChemicalBook >> CAS DataBase List >>4-Hydroxy-D-(-)-2-phenylglycine


Chemical Name:
(R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;D-4-HYDROXYPHENYLGLYCINE;4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-2-Phenylglycine amide;AMoxicillin Related CoMpound I;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;B8372699;H-D-HPG-OH;D-4-OH-Phg-OH
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2023-02-22 13:54:25

4-Hydroxy-D-(-)-2-phenylglycine Properties

Melting point 240 °C (dec.)(lit.)
alpha -156 º (c=1, 1 N HCl)
Boiling point 295.73°C (rough estimate)
Density 1.396
vapor pressure 0Pa at 25℃
refractive index -158 ° (C=1, 1mol/L HCl)
storage temp. 2-8°C
solubility 5g/l
pka 2.15±0.10(Predicted)
form Liquid
color Clear colorless to yellow
optical activity [α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility 5 g/L (20 ºC)
BRN 2210998
LogP -2.25
CAS DataBase Reference 22818-40-2(CAS DataBase Reference)
EPA Substance Registry System Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
HS Code  29225000
NFPA 704
2 0

4-Hydroxy-D-(-)-2-phenylglycine price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2196 Amoxicillin Related Compound I 22818-40-2 50MG $458 2023-01-07 Buy
Sigma-Aldrich 215333 4-Hydroxy-D-phenylglycine ≥98% 22818-40-2 25g $50.1 2023-01-07 Buy
Sigma-Aldrich 1031591 Amoxicillin Related Compound I United States Pharmacopeia (USP) Reference Standard 22818-40-2 25mg $1310 2022-05-15 Buy
TCI Chemical H0758 4-Hydroxy-D-(-)-2-phenylglycine >99.0%(HPLC)(T) 22818-40-2 25g $36 2023-01-07 Buy
TCI Chemical H0758 4-Hydroxy-D-(-)-2-phenylglycine >99.0%(HPLC)(T) 22818-40-2 100g $70 2023-01-07 Buy
Product number Packaging Price Buy
PHR2196 50MG $458 Buy
215333 25g $50.1 Buy
1031591 25mg $1310 Buy
H0758 25g $36 Buy
H0758 100g $70 Buy

4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties,Uses,Production

Chemical Properties

off-white powder


4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.


4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.


ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility


Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Suppliers

Global( 486)Suppliers
Supplier Tel Email Country ProdList Advantage
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106 China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29810 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 17713 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21975 55
Guangzhou PI PI Biotech Inc
+86-020-81716320 +86-18371201331 China 3635 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 China 2990 55
career henan chemical co
+86-0371-86658258 China 29922 58
Accela ChemBio Inc.
(+1)-858-699-3322 United States 19965 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 China 7847 58
Hubei xin bonus chemical co. LTD
86-13657291602 CHINA 22973 58

View Lastest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Hydroxy-D-(-)-2-phenylglycine pictures 2023-03-28 4-Hydroxy-D-(-)-2-phenylglycine
US $72.00-60.00 / kilograms 10kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
D(-)-4-Hydroxyphenylglycine pictures 2023-03-06 D(-)-4-Hydroxyphenylglycine
US $10.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
4-Hydroxy-D-(-)-2-phenylglycine pictures 2023-02-10 4-Hydroxy-D-(-)-2-phenylglycine
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
4-HYDROXY-D-PHENYLGLYCINE (R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID (R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID (r)-alpha-amino-4-hydroxybenzeneacetic acid (R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID (R)-4-HYDROXYPHENYLGLYCINE (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE D-(-)-2-(4-HYDROXYPHENYL)GLYCINE D(-)-2-(P-HYDROXYPHENYL)GLYCINE D-(-)-A-4-HYDROXYPHENYLGLYCINE D-4-HYDROXYPHENYLGLICYNE D-(-)-4-HYDROXYPHENYLGLYCINE D-4-HYDROXYPHENYLGLYCINE D-ALPHA-PARA-HYDROXYPHENYLGLYCINE (D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE D-(-)-P-HYDROXYPHENYLGLYCINE D-P-HYDROXYPHENYLGLYCINE D(-)PARA-HYDROXY-PHENYLGLYCINE HYDROXY PHENYL GLYCINE H-D-HPG-OH H-D-PHG(4-OH)-OH H-D-PHG(4-HYDROXY)-OH Cefoperazone Impurity 3 Amoxicillin Impurity 8(EP Impurity I) Cefprozil Impurity 1(Cefprozil EP Impurity A) Cefadroxil Impurity 7(Cefadroxil EP Impurity A) D-(-)Pare Hydroxyphenylglycine (theta)-benzeneaceticaci .alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid a-Amino-p-hydroxyphenylaceticacid Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)- Benzeneaceticacid,-amino-4-hydroxy-,(R)- L-(-)-4-Hydroxy-α-aminophenylacetic acid D(-)-P-Hydroxyphenylglycine, 98+% (2R)-2-(4-Hydroxyphenyl)glycine (R)-2-(p-Hydroxyphenyl)glycine p-Hydroxy-D-phenylglycine α-(4-Hydroxyphenyl)-D-glycine (2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid) D(-)-4-Hydroxyphenylglycine, 98+% 100GR D(-)-4-Hydroxyphenylglycine, 98+% 25GR D(-)-4-Hydroxyphenylglycine ,99% D(-)-alpha-para-Hydroxyphenylglycine base (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)- 4-Hydroxy-D-(-)-2-phenylglycine (R)-2-AMino-2-(4-hydroxyphenyl)acetic acid AMoxicillin EP IMpurity I (-)-4-Hydroxy-D-phenylglycine, 98+% D-(-)p-hydroxyphenylgcine Dane salt AMoxicillin Related CoMpound I 4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine Cefprozil impurity A Cefadroxyl impurity A Cefprozil Monohydrate EP Impurity A (2R)-2-ammonio-2-(4-hydroxyphenyl)acetate