ChemicalBook >> CAS DataBase List >>4'-Hydroxyacetophenone


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Modify Date:2023-03-20 18:30:58

4'-Hydroxyacetophenone Properties

Melting point 132-135 °C(lit.)
Boiling point 147-148 °C3 mm Hg(lit.)
Density 1.109
vapor pressure 0.002Pa at 20℃
refractive index 1.5577 (estimate)
Flash point 166 °C
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
form Crystalline Powder
pka 8.05(at 25℃)
color Almost white to beige
Specific Gravity 1.109
Water Solubility 10 g/L (22 ºC)
JECFA Number 2040
BRN 774355
LogP 1.35 at 25℃
Substances Added to Food (formerly EAFUS) 4-HYDROXYACETOPHENONE
CAS DataBase Reference 99-93-4(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4)
EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H319-H412
Precautionary statements  P264-P273-P280-P305+P351+P338-P337+P313-P501
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  26-36/37-37/39-24/25-22-36
WGK Germany  3
RTECS  PC4959775
Hazard Note  Irritant
HS Code  29145000
NFPA 704
2 0

4'-Hydroxyacetophenone price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 SAMPLE $50 2023-01-07 Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 100G $150 2023-01-07 Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 1KG $325 2023-01-07 Buy
Sigma-Aldrich PHL80232 4′-Hydroxyacetophenone phyproof? Reference Substance 99-93-4 100MG $250 2023-01-07 Buy
Sigma-Aldrich BP770 4′-Hydroxyacetophenone British Pharmacopoeia (BP) Reference Standard 99-93-4 25MG $246 2023-01-07 Buy
Product number Packaging Price Buy
W433055 SAMPLE $50 Buy
W433055 100G $150 Buy
W433055 1KG $325 Buy
PHL80232 100MG $250 Buy
BP770 25MG $246 Buy

4'-Hydroxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

almost white to beige crystalline powder

Chemical Properties

White to beige powder; sweet, hawthorn, balsam, mimosa aroma


Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.


4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.


4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.


p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry.


Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.


ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.

Aroma threshold values

Floral type, medium strength odor; recommend smelling in a 10.00% solution or less.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Flammability and Explosibility


Purification Methods

Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]

4'-Hydroxyacetophenone Suppliers

Global( 830)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
13231137666 +8615028179902 China 2991 58
+86-15013270415 China 243 58
Shandong Believe Chemical PTE.LTD
+8618553607090 China 1750 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29810 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 17713 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21975 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9381 55
21-51619050 China 31382 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 China 2990 55

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View Lastest Price from 4'-Hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Hydroxyacetophenone pictures 2023-03-29 4'-Hydroxyacetophenone
US $5.00 / kg 10kg 99% 20tons Hebei Linwo New Material Technology Co., LTD
4'-Hydroxyacetophenone pictures 2023-03-28 4'-Hydroxyacetophenone
US $1.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD
4'-Hydroxyacetophenone pictures 2023-03-24 4'-Hydroxyacetophenone
US $45.00 / KG 1KG 98% 20t/month Hebei Yime New Material Technology Co., Ltd.
1-(4-hydroxyphenyl)-ethanon 4’-hydroxy-acetophenon 4-Hydroksyacetofenol Acetophenone, p-hydroxy- Ethanone, 1-(4-hydroxyphenyl)- Hydroxyacetophenone, para HYDROXYACETOPHENONE-4 HYDROXYBENZOPHENONE-4 ACETYLPHENOL AKOS BBS-00003226 4-ACETOPHENOL 4-ACETYLPHENOL 4-BENZOYLPHENOL 4'-HYDROXYACETOPHENONE 4-HYDROXYACETOPHENONE 4-HYDROXYPHENYL METHYL KETONE 1-(4-HYDROXY-PHENYL)-ETHANONE 4'-Hydroxyacetophenone 4-Acetylphenol 4-HydraxyAcetophenone 4-HYDROXY ACETOPHENONE (p-HYDROXY ACETOPHENONE) 4'-Hydroxyacetophenone,99% 4-HYDROXYLACETOPHENONE PARA-METHYLKETOPHENOL PARA-ACETYLPHENOL Acetophenone,4'-hydroxy- D-Hydroxyacetophehone 4''-HYDROXYACETOPHENONESALBUTAMOL 4'-Hydroxyacetophenone,98% Hydroxyce Tophenone Acetaminophen Impurity E LGB-HAP 2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one Paracetamol EP Impurity E (4'-Hydroxyacetophenone) 4'-Hydroxyacetophenone IN STOCK 4'-Hydroxyacetophenone factory China 4'-Hydroxyacetophenone Factory 4-Acetylphenol Methyl p-hydroxyphenyl ketone methyl-p-hydroxyphenylketone p-Acetylphenol para-Hydroxyacetophenone Phenol, p-acetyl- p-hydroxy-acetophenon p-Hydroxyphenyl methyl ketone p-hydroxyphenylmethylketone Piceol p-Oxyacetophenone USAF kf-15 usafkf-15 POB P-HYDROXYACETOPHENONE P-HYDROXYBENZOPHENONE P-BENZOYLPHENOL P-ACETOPHENOL 1-(4-hydroxyphenyl)-1-ethanone HYDROXYACETOPHENONE, P- (RG) 4'-Hydroxyacetophene 4'-Hydroxyacetopheno Methyl 4-Hydroxyphenyl Ketone